1.基本信息
姓名：孔北华
性别：男
出生年月：1961年8月
职称：山东大学齐鲁医学部常务副部长、教授
电话：18560081888
邮箱：kongbeihua@sdu.edu.cn
2.个人简介
教授，博士生导师，山东省“泰山学者”特聘专家。山东大学医学部常务副部长、妇产科学系主任，齐鲁医院妇产科学科带头人。从事妇产科临床医疗、教学、科研30余年，主攻方向为妇科肿瘤临床诊治和分子生物学研究。主持国家“863”课题“卵巢癌分子网络研究及应用”，主持其他国家及省部级科学研究项目20余项，发表妇科肿瘤学术研究论文200余篇, 其中SCI 收录60余篇，获得省部级科技进步奖6项,其中主持的妇科肿瘤项目获国家教育部科技进步一等奖2项。主持制定了国家卫生行业标准《子宫颈癌诊断》，主编国家级十一五规划教材《妇产科学》（高等教育出版社），副主编卫生部规划教材5、7、8年制《妇产科学》教材。培养硕士研究生70余名、博士研究生50余名。目前在山东大学医药卫生管理学院招收公共卫生(医院管理方向)专业硕士。
3.教育经历
1978.09-1983.07，山东医科大学临床医学专业，学士学位；
1985.09-1990.12，山东医科大学妇产科学硕博连读；
1993.09-1996.03，日本医科大学任客员研究员
4.工作经历
1983.08~1985.10，山东大学齐鲁医院，妇产科，住院医师；
1990.12~1993.08，山东大学齐鲁医院，妇产科，主治医师；
1996.04~1999.01，山东大学齐鲁医院，妇产科，副主任医师；
1999.01~至今，山东大学齐鲁医院，妇产科，主任医师；
1997.07~2014.07，山东大学齐鲁医院，妇产科，科主任；
1999.10~2015.07，山东大学齐鲁医院，副院长
2015.08~今，山东大学齐鲁医学部常务副部长
5.学术兼职
现任中华医学会妇产科分会副主任委员，中华医学会妇科肿瘤分会副主任委员，中国医师协会妇产科分会副会长，《中华妇产科杂志》副总编，国家执业医师考试临床医学命审题委员会副主任委员兼妇科学组组长，山东省医师协会妇产科主任委员，现代妇产科进展杂志主编。十一届全国人大代表。
6.研究领域
妇科肿瘤的临床诊治及基础研究
7.研究课题
l hES诱导的造血干细胞增强卵巢癌化疗疗效的实验研究 国家自然科学基金 项目主持人
l 优生优育关键技术创新研究与示范 山东省科技发展重大专项 项目主持人
l 肿瘤相关抗原CHP2对卵巢癌生物学行为的影响及其机制探讨 国家自然科学基金 项目主持人
l 荧光原位杂交技术(FISH)在产前遗传性疾病和部分肿瘤检测的临床应用研究 卫生部 项目主持人
l 社区医疗机构在宫颈病变防治中的作用研究 国家科技支撑计划子课题 项目主持人
l 卵巢癌早期诊断分子标志物的筛选及功能分析 国家自然科学基金 项目主持人
l 国家临床重点专科项目建设经费 卫生部 项目主持人
l 液基细胞学、HPV检测及hTERC、C-MYC基因检测在宫颈癌筛查中的相关性研究 中华医学会 项目主持人
l 卵巢癌分子分型和个体化诊疗技术 863计划子课题 项目主持人
l 卵巢癌的蛋白质分子网络研究 863计划 项目主持人
l 卵巢低级别浆液性癌输卵管起源的分子机制研究 国家自然科学基金 项目主持人
l 生殖与生育重大疾病诊治的规范化与推广 卫生部卫生公益性行业科研专项子课题 项目主持人
8.科研产出（论文、著作、奖励等）
SCI论文
1) Yuan C, Liu X, Yang N, Liu Z, Yan S, Shen K, Kong B. The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis. PLoS One 2015, 10(9):e0138692.
2) Yan S, Yuan C, Yang Q, Li X, Yang N, Liu X, Dong R, Zhang X, Yuan Z, Zhang N, Kong B. A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with ovarian cancer susceptibility. Oncol Rep 2015, 34(4):2151-5.
3) Yan L, Liu X, Yin A, Wei Y, Yang Q, Kong B. Huaier aqueous extract inhibits cervical cancer cell proliferation via JNK/p38 pathway. Int J Oncol 2015, 47(3):1054-60.
4) Wang L, Kong B. Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer. Int J Gynecol Cancer 2015, 25(6):961-7.
5) Liu X, Dong R, Jiang Z, Wei Y, Li Y, Wei L, Sun H, Yang N, Yang Q, Liu Z, Kong B. MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition. TumourBiol 2015.
6) Jin C, Dong R, Bu H, Yuan M, Zhang Y, Kong B. Coexistence of benign strumaovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. Oncol Lett 2015, 9(4):1739-42.
7) Jia L, Yuan Z, Wang Y, Cragun JM, Kong B, Zheng W. Primary sources of pelvic serous cancer in patients with endometrial intraepithelial carcinoma. Mod Pathol 2015, 28(1):118-27.
8) Dong R, Jin C, Zhang Q, Yang X, Kong B. Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. Oncol Rep 2015.
9) Zhang Q, Ubago J, Li L, Guo H, Liu Y, Qiang W, Kim JJ, Kong B, Wei JJ. Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma. Cancer 2014, 120(20):3165-77.
10) Yuan Z, Wang L, Wang Y, Zhang T, Li L, Cragun JM, Chambers SK, Kong B, Zheng W. Tubal origin of ovarian endometriosis. Mod Pathol 2014.
11) Yuan C, Liu X, Yan S, Wang C, Kong B. Analyzing association of the XRCC3 gene polymorphism with ovarian cancer risk. Biomed Res Int 2014, 2014:648137.
12) Xu X, Ayub B, Liu Z, Serna VA, Qiang W, Liu Y, Hernando E, Zabludoff S, Kurita T, Kong B, Wei JJ. Anti-MiR-182 reduces ovarian cancer burden, invasion and metastasis: An in vivo study in orthotopic xenografts of nude mice. Mol Cancer Ther 2014.
13) Wang Y, Yan S, Liu X, Zhang W, Li Y, Dong R, Zhang Q, Yang Q, Yuan C, Shen K, Kong B. miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma. Oncol Rep 2014, 31(4):1905-10.
14) Jia L, Ren JM, Wang YY, Zheng Y, Zhang H, Zhang Q, Kong BH, Zheng WX. Inhibitory role of prohibitin in human ovarian epithelial cancer. Int J ClinExpPathol 2014, 7(5):2247-55.
15) Dong R, Liu X, Zhang Q, Jiang Z, Li Y, Wei Y, Yang Q, Liu J, Wei JJ, Shao C, Liu Z, Kong B. miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma. Oncotarget 2014, 5(21):10816-29.
16) Zhang S, Hou X, Zi S, Wang Y, Chen L, Kong B. Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients. Cell PhysiolBiochem 2013, 31(4-5):525-31.
17) Zhang Q, Hu G, Yang Q, Dong R, Xie X, Ma D, Shen K, Kong B. A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA. GynecolOncol 2013, 130(1):132-9.
18) Yan S, Wang Y, Yang Q, Li X, Kong X, Zhang N, Yuan C, Yang N, Kong B. Low-dose radiation-induced epithelial-mesenchymal transition through NF-kappaB in cervical cancer cells. Int J Oncol 2013, 42(5):1801-6.
19) Xu X, Dong Z, Li Y, Yang Y, Yuan Z, Qu X, Kong B. The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation. Int J Biochem Cell Biol 2013, 45(3):536-45.
20) Xiang L, Kong B. PAX8 is a novel marker for differentiating between various types of tumor, particularly ovarian epithelial carcinomas. Oncol Lett 2013, 5(3):735-8.
21) Song K, Xu P, Meng Y, Geng F, Li J, Li Z, Xing J, Chen J, Kong B. Smart gold nanoparticles enhance killing effect on cancer cells. Int J Oncol 2013, 42(2):597-608.
22) Liu XL, Yang QF, Kong BH. Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis. Genet Mol Res 2013, 12(2):1924-33.
23) Li J, Ning Y, Abushahin N, Yuan Z, Wang Y, Yuan B, Cragun JM, Chambers SK, Hatch K, Kong B, Zheng W. Secretory cell expansion with aging: Risk for pelvic serous carcinogenesis. GynecolOncol 2013, 131(3):555-60.
24) Gu W, Wang C, Li W, Hsu FN, Tian L, Zhou J, Yuan C, Xie XJ, Jiang T, Addya S, Tai Y, Kong B, Ji JY. Tumor-suppressive effects of CDK8 in endometrial cancer cells. Cell Cycle 2013, 12(6):987-99.
25) Fang Y, Yu S, Ma Y, Sun P, Ma D, Ji C, Kong B. Association of Dll4/notch and HIF-1a -VEGF signaling in the angiogenesis of missed abortion. PLoS One 2013, 8(8):e70667.
26) Ban Y, Chang Y, Dong B, Kong B, Qu X. Indoleamine 2,3-dioxygenase levels at the normal and recurrent spontaneous abortion fetal-maternal interface. J Int Med Res 2013, 41(4):1135-49.
27) Zhao Y, Moran MS, Yang Q, Liu Q, Yuan C, Hong S, Kong B. Metadherin regulates radioresistance in cervical cancer cells. Oncol Rep 2012, 27(5):1520-6.
28) Zhang H, Jia L, Zhang Q, Zhang Y, Yang X, Kong B. Therapeutic role of systematic retroperitoneal lymphadenectomy in endometrial cancer. Bull Cancer 2012, 99(2):10-7.
29) Yuan C, Li X, Yan S, Yang Q, Liu X, Kong B. The MTDH (-470G>A) Polymorphism Is Associated with Ovarian Cancer Susceptibility. PLoS One 2012, 7(12):e51561.
30) Xu X, Wang Q, Deng B, Wang H, Dong Z, Qu X, Kong B. Monocyte Chemoattractant Protein-1 Secreted by Decidual Stromal Cells Inhibits NK Cells Cytotoxicity by Up-Regulating Expression of SOCS3. PLoS One 2012, 7(7):e41869.
31) Xiang L, Zheng W, Kong B. Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology. GynecolOncol 2012.
32) Wei W, Kong B, Qu X. Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features. J ObstetGynaecol Res 2012, 38(1):57-64.
33) Li J, Fadare O, Xiang L, Kong B, Zheng W. Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis. J HematolOncol 2012, 5:8.
34) Jia L, Zhang H, Qu X, Deng B, Kong B. Proteomic analysis reflects different histologic subtypes of epithelial ovarian cancer. Med Hypotheses 2012, 78(3):407-9.
35) Hong S, Zhang P, Zhang H, Jia L, Qu X, Yang Q, Rong F, Kong B. Enforced effect of tk-MCP-1 fusion gene in ovarian cancer. J ExpClin Cancer Res 2012, 31:74.
36) Hong S, Li X, Zhao Y, Yang Q, Kong B. 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway. Oncol Rep 2012, 27(4):1251-7.
37) Yao Q, Cao S, Li C, Mengesha A, Kong B, Wei M. Micro-RNA-21 regulates TGF-beta-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. Int J Cancer 2011, 128(8):1783-92.
38) Song K, Li J, Li L, Zhang P, Geng F, Dong R, Yang Q, Qu X, Kong B. Intracellular metabolism, subcellular localization and phototoxicity of HMME/HB in ovarian cancer cells. Anticancer Res 2011, 31(10):3229-35.
39) Li Y, Zhao H, Sun L, Huang L, Yang Q, Kong B. MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis. Hum Cell 2011, 24(2):57-64.
40) Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B, Zheng W. Tubal origin of 'ovarian' low-grade serous carcinoma. Mod Pathol 2011, 24(11):1488-99.
41) Jia L, Yi XF, Zhang ZB, Zhuang ZP, Li J, Chambers SK, Kong BH, Zheng W. Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis. Neoplasma 2011, 58(2):104-9.
42) Geng F, Song K, Xing JZ, Yuan C, Yan S, Yang Q, Chen J, Kong B. Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer. Nanotechnology 2011, 22(28):285101.
43) Fang Y, Kong B, Yang Q, Ma D, Qu X. The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion. Hum Reprod 2011, 26(5):1252-8.
44) Chen N, Yi X, Abushahin N, Pang S, Zhang D, Kong B, Zheng W. Nrf2 expression in endometrial serous carcinomas and its precancers. Int J ClinExpPathol 2011, 4(1):85-96.
45) Wei W, Kong B, Yang Q, Qu X. Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1. Cancer BiolTher 2010, 9(2):79-87.
46) Sun L, Kong B, Sheng X, Sheu JJ, Shih Ie M. Dendritic cells transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes against ovarian cancer in vitro. BiochemBiophys Res Commun 2010, 394(3):633-8.
47) Qiu H, Zhu J, Yuan C, Yan S, Yang Q, Kong B. Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer. Cancer Sci 2010.
48) Zhang X, Liang SX, Jia L, Chen N, Fadare O, Schwartz PE, Kong B, Zheng W. Molecular identification of "latent precancers" for endometrial serous carcinoma in benign-appearing endometrium. Am J Pathol 2009, 174(6):2000-6.
49) Yao Q, Qu X, Yang Q, Wei M, Kong B. CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblasttransdifferentiation in ovarian cancer. Oncol Rep 2009, 22(3):541-8.
50) Song X, Kong B, Li D, Yang Q. The inhibitory effect of human embryonic germ cells on ovarian cancer. Neoplasma 2009, 56(1):13-21.
51) Fang Y, Kong B, Yang Q, Ma D, Qu X. MDM2 309 polymorphism is associated with missed abortion. Hum Reprod 2009, 24(6):1346-9.
52) Wang X, Wei Z, Gao F, Zhang X, Zhou C, Zhu F, Wang Q, Gao Q, Ma C, Sun W, Kong B, Zhang L. Expression and prognostic significance of PDCD4 in human epithelial ovarian carcinoma. Anticancer Res 2008, 28(5B):2991-6.
53) Song X, Kong B, Li D. A new tool for probing of cell-cell communication: human embryonic germ cells inducing apoptosis of SKOV3 ovarian cancer cells on a microfluidic chip. Biotechnol Lett 2008, 30(9):1537-43.
54) Qu X, Yang M, Zhang W, Liang L, Yang Y, Zhang Y, Deng B, Gao W, Liu J, Yang Q, Kong B, Gong F. Osteopontin expression in human decidua is associated with decidual natural killer cells recruitment and regulated by progesterone. In Vivo 2008, 22(1):55-61.
55) Jia L, Liu Y, Yi X, Miron A, Crum CP, Kong B, Zheng W. Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinoma. Clin Cancer Res 2008, 14(8):2263-9.
56) Guo WJ, Qu X, Yang MX, Zhang WD, Liang L, Shao QQ, Kong BH. Expression of BAFF in the trophoblast and decidua of normal early pregnant women and patients with recurrent spontaneous miscarriage. Chin Med J (Engl) 2008, 121(4):309-15.
57) Ban YL, Kong BH, Qu X, Yang QF, Ma YY. BDCA-1+, BDCA-2+ and BDCA-3+ dendritic cells in early human pregnancy decidua. ClinExpImmunol 2008, 151(3):399-406.
58) Wei Y, Kong B, Song K, Qu X, Jin Q, Yang Q. Involvement of mitochondria-caspase pathway in Hemoporfin-mediated cell death. PhotochemPhotobiol 2007, 83(6):1319-24.
59) Song K, Kong B, Li L, Yang Q, Wei Y, Qu X. Intraperitoneal photodynamic therapy for an ovarian cancer ascite model in Fischer 344 rat using hematoporphyrin monomethyl ether. Cancer Sci 2007, 98(12):1959-64.
60) Jin Q, Kong B, Yang X, Cui B, Wei Y, Yang Q. Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer. In Vivo 2007, 21(4):593-8.
61) Zhang H, Kong B, Qu X, Jia L, Deng B, Yang Q. Biomarker discovery for ovarian cancer using SELDI-TOF-MS. GynecolOncol 2006, 102(1):61-6.
62) Song Y, Kong B, Ma D, Qu X, Jiang S. Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer. Int J Gynecol Cancer 2006, 16(1):156-64.
63) Song K, Kong B, Qu X, Li L, Yang Q. Phototoxicity of Hemoporfin to ovarian cancer. BiochemBiophys Res Commun 2005, 337(1):127-32.
64) Kong B, Huang S, Wang W, Ma D, Qu X, Jiang J, Yang X, Zhang Y, Wang B, Cui B, Yang Q. Arsenic trioxide induces apoptosis in cisplatin-sensitive and -resistant ovarian cancer cell lines. Int J Gynecol Cancer 2005, 15(5):872-7.
65) Jiang J, Kong B, Shen B, Li L, Yang X, Hou H, Shi Q, Ma D, Ma X. High dose chemotherapy and transplantation of hematopoietic progenitors from murine D3 embryonic stem cells. J Chemother 2005, 17(3):302-8.
66) Kong B, Wang W, Liu C, Song L, Ma D, Qu X, Jiang J, Yang X, Zhang Y, Wang B, Wei MQ, Yang Q. Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer. In Vivo 2003, 17(2):153-6.
67) Kong B, Isozaki T, Sasaki S. IL-6 antisense-mediated growth inhibition of a choriocarcinoma cell line: an intracellular autocrine growth mechanism. GynecolOncol 1996, 63(1):78-84.
科研奖励
1) 卵巢癌早期诊断和综合治疗技术 孔北华、张辉、杨兴升、张友忠、姜洁、王波、崔保霞、宋坤、孟丽华、王文霞、孙平 2010 教育部提名科技进步奖 一等奖
2) 卵巢癌基础与临床研究 孔北华，张辉，宋坤，孟丽华，王文霞，杨兴升，张友忠，王波，姜洁 2010 山东省科技进步奖 二等奖
3) 卵巢癌基因治疗关键技术研究 孔北华，宋坤，王文霞，宋悦，金平，张萍，洪淑惠，靳琼 2008 山东省科技进步奖 二等奖
4) 卵巢癌基因治疗关键技术研究 孔北华，宋坤，王文霞，宋悦，金平，张萍，洪淑惠，靳琼 2008 中华医学科技奖奖 三等奖
5) 抗体导向自杀基因治疗卵巢癌的实验研究 孔北华，刘春生，王文霞等 2002 教育部提名国家科技进步奖 一等奖
6) 抗MUC-1靶向的慢病毒高效转导 VP22/HSV-tk融合基因治疗卵巢癌的实验研究 孔北华，刘春生，姜洁，宋莉，马道新 2001 山东省科技进步奖 二等奖
7) 整体化临床教学改革研究 孔北华，纪春岩，肖伟，马榕，李晶晶 2009 山东省教学成果奖 一等奖
8) 三氧化二砷用于人卵巢癌化学治疗的实验研究 孔北华，黄守国，马玉燕，杨瑞芳，王明毅 2003 教育部提名国家科技进步奖 二等奖
9) 宫腔内窥手术钳的研制及应用 董白桦，孔北华，苏士利，孙丙翠，殷宪明，刘瑾，李恒卫，李涛 2010 山东省科技进步奖 二等奖
10) 高清晰宫腔操作可视系统的研制及应用研究 董白桦，孔北华，苏士利，顾爱远，魏艳秋，孙丙翠，胡颖，赵真 2011 全国人口和计划生育优秀科技成果奖二等奖
论著
